Their work, published in Nature Communications, reveals a mechanism of interdependence of different forms of the cytoskeletal proteins actin and myosin, and their functions. The team also ...

Upon ligand binding, G-protein-coupled receptors (GPCRs) catalyse the exchange of GDP to GTP on the α-subunit ... for example, of actin polymerization and other responses. As Janetopoulos ...

The proteins of the formin family are pivotal ... the mechanism," say Oosterheert and Boiero Sanders. When the new actin subunit arrives, its incorporation onto the filament destabilizes the ...

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family.

Actin proteins group together to form a network of thin filaments that spread throughout eukaryotic cells. These filaments are involved in giving the cell its structure, allowing the cell to move, and ...