a physiologically relevant nucleator should produce filaments that elongate from their barbed ends; third, a nucleator must recruit profilin-bound ATP–actin for filament assembly, either ...

Space-filling model from molecular dynamics simulation showing actin filament barbed end (blue) and pointed end (red). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...

"But those studies lacked high-resolution structures of formins bound to their relevant sites of activity, the barbed end of actin filaments," says Wout Oosterheert, postdoc in the group of ...

"But those studies lacked high-resolution structures of formins bound to their relevant sites of activity, the barbed end of ...

These protrusive structures contain actin filaments, with elongating barbed ends orientated toward the plasma membrane. (B) During cellular arm extension, the plasma membrane sticks to the surface ...