Julius and colleagues have shown that a range of pain-inducing toxins and inflammatory compounds derived from sources as diverse as spider toxins and plants will also activate TRPV1, links that have ...

In a technical tour de force, UC San Francisco scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

In a technical tour de force, UC San Francisco (UCSF) scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

In a technical tour de force, scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat. In a technical tour de ...

Julius and colleagues have shown that a range of pain-inducing toxins and inflammatory compounds derived from sources as diverse as spider toxins and plants will also activate TRPV1, links that have ...

The structure of a protein that plays a central role in the perception of pain and heat has been unveiled by UC San Francisco (UCSF) scientists. Led by UCSF postdoctoral fellows Erhu Cao ...

Known as TRPV1, the protein was discovered more than 15 years ago. Although scientists knew that it could sense heat and various chemicals, exactly how it worked remained a mystery. In December, ...

In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...

Understanding these proteins’ thermal activation mechanisms could be essential for developing new pain therapies, Qin says ... To do so, the researchers say they’ll need to further investigate the ...

This 3D structure is essential for the function of proteins and can help us understand how proteins misbehave after they pick up mutations or allow us to design drugs to inactivate the proteins of ...