The motor endplate contains specialized ligand-gated, nicotinic acetylcholine receptors (nAChRs), which convert the chemical signal (i.e., binding of two acetylcholine molecules) into electrical ...

Antibodies against the ganglionic acetylcholine receptors were ... which consists of two acetylcholine receptor alpha-1 subunits in combination with beta-1, delta, and epsilon subunits. ...

NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death.There's no ...

BUFFALO, N.Y. -- A formerly unknown action of the acetylcholine receptor channel, a protein that regulates the electrical activity of nerve and muscle cells, is described by biophysicists at the ...

Katyal N, Govindarajan R, Goyal N, et al. Ravulizumab use for acetylcholine receptor-positive generalized myasthenia gravis in clinical practice. Front Neurol . 2024;15:1378080. doi:10.3389/fneur ...

Bionomics has collaborated with MSD to identify novel α7 nAChR PAMs suitable for the treatment of cognitive disorders like Alzheimer’s DiseaseBased on the learnings from Bionomics’ candidate ...

Certain antibodies block the regular acetylcholine binding process, the researchers found, while others activate the immune system's complement pathway, leading to receptor destruction.

uplizna® (inebilizumab-cdon) significantly improves generalized myasthenia gravis symptoms in acetylcholine receptor autoantibody-positive patients over 52 weeks. amgen. march 13, 2025. accessed march ...

Amgen (NASDAQ:AMGN) today announced new data from the Phase 3, registrational MINT trial evaluating the efficacy and safety of UPLIZNA® (inebilizumab-cdon) in adults living with generalized ...