Simply put, higher levels of acetylation, shorten the effect of cortisol," explains Dr. Aishwarya Iyer-Bierhoff, the first author of the study. Elucidation of this regulatory mechanism opens up ...

NatA complex: A protein complex responsible for the N-terminal acetylation of a large number of proteins in eukaryotic cells. Ubiquitin-proteasome system: A cellular mechanism that degrades and ...

McC analogs with an altered terminal amino acid retain the Trojan-horse mechanism of action but ... inside the producing cell is inactivated by acetylation catalyzed by the C-terminal domain ...