but the mechanisms regulating PDC activity—especially through post-translational modifications like acetylation—remain poorly ...

However, the molecular mechanisms that underlie abnormal tau ... SIRT1 is a deacetylase, an enzyme that removes acetyl groups from proteins. Like phosphorylation, acetylation regulates many ...

Acetylation is a chemical reaction that is called ethanoylation in the IUPAC nomenclature. It describes a reaction that introduces an acetyl functional group into a chemical compound. The opposite ...

when an acetyl group is transferred to the protein. The role of the 'driver' is played by enzymes, so-called acetyltransferases. Not much is known, however, about the precise mechanisms underlying ...

Simply put, higher levels of acetylation, shorten the effect of cortisol," explains Dr. Aishwarya Iyer-Bierhoff, the first author of the study. Elucidation of this regulatory mechanism opens up ...

the researchers discovered that the sites where CREB interacted with DNA to promote gene expression require prior acetylation mediated by CBP. "These findings not only elucidate the mechanism ...

Microtubule acetylation is essential for many cellular functions and has been linked to various health conditions, including cancer and brain disorders. Until this study, the molecular mechanism ...

As they expected, Bub1 acetylation enhances its kinase activity, thereby promoting the phosphorylation of H2A. “This is the mechanism by which Bub1 acetylation regulates chromosome congression ...

A cable drum (consisting of four pairs of histones) ... The "read–write" mechanism by which cells replicate and use chemical instructions for expressing genes has been uncovered by RIKEN ...