AMPK及其同系物的进化使细胞能量稳态的精确响应和控制成为可能。 AMPK及其同系物的进化使细胞能量稳态的精确响应和控制成为可能。最近的工作在 ...

AMPK及其同系物的进化使细胞能量稳态的精确响应和控制成为可能。 AMPK及其同系物的进化使细胞能量稳态的精确响应和控制成为可能。最近的工作在 ...

实验数据显示，使用ampk激动剂aicar处理hev感染的肝细胞后，病毒基因组rna水平在48小时内下降38.5%，且效果呈剂量依赖性；而抑制ampk活性或敲除其亚 ...

首次从“时空”的角度去探索AMPK的生理意义，提供了本领域期待已久的 “全景图”。 AMPK是有机体和细胞内感应能量水平并调节代谢稳态最重要的分子。以AMPK为靶标、通过药物使其激活，有着缓解糖尿病、延缓衰老以及降低肿瘤发病风险等作用。因此，自上 ...

In mice with adenovirus-null, refeeding decreased AMPK activity in the ARH and VMH/DMH to comparable levels as DN-AMPK (Fig. 3d). In contrast, in mice with CA-AMPK, total AMPK activity in ARH and ...

后续的研究进一步从分子水平揭示了以AMPK为代表的代谢稳态维持的核心蛋白，能够在葡萄糖水平下降的情况下，通过磷酸化脂肪酸合成的关键酶ACC ...

本文聚焦代谢功能障碍相关脂肪性肝病（MASLD）肝纤维化治疗。阐述了 AMP 激活蛋白激酶（AMPK）在其中的关键调节作用，如抑制 TGF-β/SMAD 通路减轻纤维化。探讨了相关疗法进展及临床挑战，为该领域研究和治疗提供全面视角。 亮点 AMPK 已成为代谢功能障碍相关 ...

Cancer often results in weight loss due to unwanted metabolic complications. This so-called cancer cachexia is accompanied by a poor prognosis with regard to disease progression, quality of life ...

This study concludes that activation of the PPARβ/δ-AMPK pathway is an effective strategy to slow the development of liver fibrosis. The paper, published in the journal Biomedicine ...

He found that the drug activated AMPK, an enzyme involved in cell growth and metabolism that has been found to play a role in cancer and diabetes. “This is an ancient herbal remedy which has ...