Under glucose starvation, AMPK promotes autophagy by directly activating ... These cell lysates were used for western analyses. For immunoprecipitation, the indicated antibody was coupled with ...

AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains metabolic homeostasis by reprogramming growth, metabolism, and autophagy in the face of ...

Akt may also negatively regulate autophagy by phosphorylating Beclin 1. AMP-activated protein kinase (AMPK), which is regulated by AMP levels, negatively regulates mTOR and also directly ...

In addition, a low-energy status activates ULK1/2 through AMP-activated protein kinase (AMPK). The second signal class involves autophagy cargoes, such as damaged mitochondria, which can also ...

The three main kinases that regulate autophagy are protein kinase A (PKA), 5’-AMP-activated protein kinase (AMPK) and mTOR complex 1 (mTORC1). mTORC1 is sensitive to both growth factors and ...

"A really interesting finding was when Matt (lead author of the study, Matthew Ulgherait) activated AMPK in the nervous system, he saw evidence of increased levels of autophagy in not only the ...

Conversely, autophagy is inhibited by mTOR, a sensor of nutrient availability and recipient of growth factor signaling. AMPK activation may interfere with mTOR-mediated inactivation of ULK1.

The researchers also identified a decline in autophagy-regulating pathways, such as mTORC1 hyperactivation and reduced AMPK activity, with age. In Alzheimer's disease, autophagy impairment was ...

The director activates AMPK, which sets increased autophagy in motion. This in turn influences how our actors, NPY and POMC, behave on a genetic level similar to a movie that tells a story of ...

"This process, called autophagy, is what cells use to recycle their trash. The process malfunctions in NPC1 and a number of neurodegenerative diseases, making the AMPK enzyme a potential target ...

Conversely, autophagy is inhibited by mTOR, a sensor of nutrient availability and recipient of growth factor signaling. AMPK activation may interfere with mTOR-mediated inactivation of ULK1.