研究发现AMPK信号通过磷酸化Beclin1的苏氨酸388位点从而调控细胞自噬，进一步揭示了自噬的发生发展的分子机制，为解析细胞自噬奠定了一定的理论基础。 自噬领域国际学术期刊Autophagy 在线发表了中国科学院上海生命科学研究院营养科学研究所刘知学组的研究 ...

AMPKα knockout cells exhibit suboptimal autophagy induction in response ... and to the rest proteins at 1:1,000 dilutions for western blot. AMPK immunoprecipitation was performed using 1 ...

AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains metabolic homeostasis by reprogramming growth, metabolism, and autophagy in the face of ...

Conversely, autophagy is inhibited by mTOR, a sensor of nutrient availability and recipient of growth factor signaling. AMPK activation may interfere with mTOR-mediated inactivation of ULK1.