Panelists explain that KMT2A-rearranged acute myeloid leukemia (AML) is an aggressive, molecularly distinct leukemia subtype marked by menin-dependent transcriptional dysregulation, poor response to ...

这篇综述聚焦急性髓系白血病（AML）治疗难题。探讨白血病干细胞（LSCs）、炎症、免疫功能障碍等因素对治疗的阻碍，如 LSCs 的耐药性、缺乏特异性标记，以及免疫微环境的不良影响，为攻克 AML 治疗困境提供思路。 引言 急性髓系白血病（AML）是一种极具异质 ...

Panelists emphasize that patients with KMT2A-rearranged acute myeloid leukemia (AML) often face steep educational challenges at diagnosis, requiring clear communication about the subtype’s ...

Understanding the fundamental molecular mechanisms underlying normal hematopoiesis and AML pathogenesis can aid the development of novel and effective targeted therapies. Prof. Wang concludes by ...

it is above all the perturbation of the RUNX1 gene -- a gene that regulates many other genes -- that seems to be responsible for AML pathogenesis. Targeting the perturbed regulator could pave the ...

An established oncogenic driver of AML pathogenesis is the FLT3 protein, which previous work has shown to be frequently mutated in AML cells. Additional work has also found that PRL2 is highly ...

while gaining an understanding of the functional characterization of AML pathogenesis. "AML is the most common type of leukemia in adults, yet the challenging nature of the disease means the 5-year ...