Predictive Safety Testing Consortium have proposed glutamate dehydrogenase (GLDH) as a more liver-specific biomarker for ...

Elevated levels of certain liver enzymes can indicate liver inflammation, injury, or disease. The ratio of AST to ALT (AST/ALT ratio or De Ritis ratio) is important. The relationship tells much ...

The U.S. Food and Drug Administration's (FDA) Biomarker Qualification Program (BQP) is currently reviewing C-Path's Full Qualification Package (FQP) to qualify GLDH as a liver safety biomarker. The ...

Researchers from Critical Path Institute’s Predictive Safety Testing Consortium have proposed glutamate dehydrogenase (GLDH) as a more liver-specific biomarker for detecting liver injury, supporting ...

Our patient's AST value was 17 times the ULN, and his ALT level was 11 times the ULN. While this is considered clinically significant, it is unknown how often ceftriaxone induces such substantial ...

Quercetin lowered levels of liver enzymes (ALT, AST) and total bile acid, markers of liver injury. Mice treated with quercetin also showed decreased collagen deposition and lower levels of ...