然而，抗体药物需要频繁重复给药，mRNA递送虽然具有快速生产的优势，但其瞬时表达特性也限制了其长期疗效。在这样的背景下，腺相关病毒（AAV ...

糖酵解衍生的乳酸被认为是组蛋白乳酸化的底物，在许多组织的转录调节中起着重要作用。然而，组蛋白乳酸化在代谢中心下丘脑中的作用尚不清楚。近期上海市第六人民医院胡承、张燚团队在Nature Communications (IF ...

For central nervous system (CNS) applications, attempts are being made to deliver AAV gene therapy directly to the brain parenchyma or the cerebrospinal fluid (CSF) space by intra-cisterna magna ...

and a polyadenylation signal (pA), which ensures proper processing and stability of the mRNA product. (2) Scientists then mix the different barcoded AAV to form an AAV pool or library. (3) Researchers ...

while AAV variants target distinct brain regions and adipose tissue. Importantly, the platform also revealed that lipid ...

AMSBIO announce a new range of ready-to-use adeno-associated virus (AAV) biosensor products. These viruses encode your chosen biosensor, either calcium or glutamate sensor and are ready for in vivo ...

In addition to the $200 million payment, Hologen will provide up to $230 million in committed funding to support the development of AAV-GAD for Parkinson's disease through commercialization.