P16 methylation plays an important role in the pathogenesis of hyperoxia-induced lung fibrosis. 5-aza-2′-deoxycytidine (5-aza-CdR) is a major methyltransferase-specific inhibitor. In this study ...

The nucleoside analog 5-aza-2′-deoxycytidine (5-aza-CdR, decitabine) is a potent inhibitor of DNA methylation in vitro. Cellular treatment with this agent induces the re-expression of ...

Results: We observed that the survival fraction of MCF-7 and MDA-MB-231 cells treated with 2um, 4um, 8um 5-aza-CdR and 0.5mM, 1mM and 2mM SB respectively was decreased in inverse proportion to the ...

The drug 5-aza-CdR is currently approved for treating a blood disorder that can lead to leukemia. It inhibits the methylation of DNA, preventing enzymes from chemically modifying genomic DNA. Such ...

The team investigated whether demethylation of gene bodies induced by the drug 5-Aza-CdR (decitabine), ... Dec 5, 2013. Study shows epigenetic changes can drive cancer. Jul 26, 2014.