Previous attempts to selectively modulate muscarinic receptors by targeting ... this site is highly conserved across the different receptor subtypes. Here, the authors show that targeting the ...

University of California has described tropane derivatives acting as 5-HT2 and muscarinic receptor ligands reported to be useful for the treatment of psychiatric disorders, depression, ...

as well as at novel serotonin receptor subtypes (5-HT 6 and 5-HT 7). Antagonism of dopamine-mediated inhibition of cAMP accumulation in C-6 cells transfected with D 2L receptors was performed as ...

Nxera and Neurocrine entered a collaboration and licensing agreement in 2021 to develop a portfolio of novel clinical and preclinical subtype-selective muscarinic M4, M1 and dual M1/M4 receptor ...