Previous attempts to selectively modulate muscarinic receptors by targeting ... this site is highly conserved across the different receptor subtypes. Here, the authors show that targeting the ...

“We had been working in the muscarinic receptor space for almost 20 years ... But because all five subtypes are widely expressed in the body, and the drug binding sites are very similar ...

A Vanderbilt University patent discloses new muscarinic M4 receptor positive allosteric modulators and agonists reported to be useful for the treatment of Alzheimer’s disease, pain, schizophrenia, ...