The properties of the different IgG isotypes should be considered in developing therapeutic antibodies. To address this problem, antibody engineers introduced a serine-to-proline substitution that ...

For example, secondary antibodies that react with IgG (H+L) will react with epitopes on both heavy and light chains, so they will react with other isotypes of primary antibody or different subtypes of ...

They engineered various isotypes of 3E1 and 9D2 antibodies bearing different heavy chains, which essentially altered the antibodies' structure and the antibody–cell interactions. Then ...

Various species might have particular subclasses or isotypes of antibodies within such five major classes. Such subclasses tend to vary in the disulfide bonds connecting the two heavy chains of ...

How different antibody isotypes, such as immunoglobulin G, A and M, arise and persist after exposure to antigens is a subject of intense investigation. Luminex, a DiaSorin company focused on ...