The properties of the different IgG isotypes should be considered in developing therapeutic antibodies. To address this problem, antibody engineers introduced a serine-to-proline substitution that ...

may also impact cross-reactivity and multiplexing. For example, secondary antibodies that react with IgG (H+L) will react with epitopes on both heavy and light chains, so they will react with other ...

How different antibody isotypes, such as immunoglobulin G, A and M, arise and persist after exposure to antigens is a subject of intense investigation. Luminex, a DiaSorin company focused on ...

They engineered various isotypes of 3E1 and 9D2 antibodies bearing different heavy chains, which essentially altered the antibodies' structure and the antibody–cell interactions. Then ...