Introduction 7α-Hydroxy-4-cholesten-3-one (C4) is the common intermediary of both primary bile acids (BAs). Its concentration in serum correlates with the rate of hepatic BA production. C4 was ...

The ratio of chenodeoxycholic:cholic acid in bile was constant (0.85) over this period and much lower than for newborn bile and adult bile indicating an immaturity in hepatic 12α-hydroxylase in ...

Guiyu Lou, Xiaoxiao Ma, Xianghui Fu, Zhipeng Meng, Wenyu Zhang, Yan-Dong Wang, Carl Van Ness, Donna Yu, Rongzhen Xu, Wendong Huang GPBAR1/TGR5 is a novel plasma membrane-bound G protein-coupled bile ...