Classical forms of congenital adrenal hyperplasia are caused by a severe deficiency of 21-hydroxylase, an enzyme involved in steroid biosynthesis, which triggers excessive androgen production ...

Congenital adrenal hyperplasia (CAH) — one of the most common autosomal recessive disorders — is potentially life-threatening in its classic (severe) form and may be asymptomatic or cause ...

Steroid 21-hydroxylase (CYP21, also termed CYP21A2 and P450c21) is a cytochrome P-450 enzyme located in the endoplasmic reticulum. It catalyzes the conversion of 17-hydroxyprogesterone to 11 ...

The most common form of congenital adrenal hyperplasia (CAH) is a condition in which the deficiency of the 21-hydroxylase enzyme results in absent or very low cortisol production. CAH differs from ...

If you were born with nonclassical congenital adrenal hyperplasia, your body doesn’t make enough of a certain enzyme called 21-hydroxylase, which affects the amount of hormones your body makes ...

A person with classic CAH does not produce the enzyme known as 21-hydroxylase, which doctors usually diagnose in newborns or early infancy. Classic CAH comes in two forms: salt-wasting and simple ...

One example is congenital adrenal hyperplasia. CAH results from an inherited alteration in a gene that blocks an essential enzyme (usually 21-hydroxylase) in the adrenal hormone pathway. Synthesis of ...

Dr. New and her colleagues have fully described the most common form of CAH: steroid 21-hydroxylase enzyme deficiency, responsible for 90-95 percent of all cases. Their previous work has led to ...

Dr. New and her colleagues have fully described the most common form of CAH: steroid 21-hydroxylase enzyme deficiency, responsible for 90-95 percent of all cases. Their previous work has led to ...

The researchers believe the hydroxylase enzyme plays an important role in human cell functions. When vitamin D drugs are used in an attempt to arrest certain types of cancer, for example ...