Men with classic 21-hydroxylase deficiency are at risk for infertility. 1 The mechanisms are complex and involve three factors: gonadotropin inhibition due to the excessive secretion of progestin ...

Yes, I do think we need non-glucocorticoid forms of therapy to treat 21-hydroxylase deficiency congenital adrenal hyperplasia.The most common form of congenital adrenal hyperplasia (CAH) is a ...

In this study, we report on three Japanese patients with cytochrome P450 oxidoreductase (POR) deficiency (PORD). Case one was a 46,XY patient who was found to have mildly increased 17α ...

A 21-hydroxylase deficiency is the most common form of CAH and affects around 1 in 10,000 to 1 in 15,000 people annually in the United States and Europe. In this article, we examine the types of ...

New observational Norwegian registry data reveal that Addison’s disease is almost exclusively autoimmune, and is associated with high autoimmune comorbidity. The observational study included a ...

Pre-pubertal gynaecomastia has been described in 11β- but not in 21-hydoxylase deficiency. An 8-yr old boy presented with bilateral 5 cm breast buds: P2 G2 Testes 2/2 ml; height 138.5 cm bone age ...

In the pediatrics study, 103 participants aged 4 to 17 years old with classic CAH due to 21-hydroxylase deficiency and inadequate androgen control on supraphysiological glucocorticoid doses were ...

This enzyme deficiency happens because of a genetic change you inherit. Without enough 21-hydroxylase, the compounds that make cortisol and the hormone aldosterone , build up in your adrenal glands.

THIS report is concerned with the delineation and biochemical demonstration of a clinical syndrome first manifest in the adult woman and resulting from an 11β-hydroxylase deficiency in the ...

In the pediatrics study, 103 participants aged 4 to 17 years old with classic CAH due to 21-hydroxylase deficiency and inadequate androgen control on supraphysiological glucocorticoid doses were ...