Sexual precocity and a testicular mass can result from a Leydig cell tumor or from simple virilizing CAH with adrenal ... and P450c17 (17 α-hydroxylase/17, 20 lyase), but no detectable mRNA ...

The most common form of CAH is caused by a deficiency in the enzyme 21-hydroxylase, which is crucial for the production of cortisol and aldosterone. This condition can result in serious health ...

and pharmacokinetics of atumelnant when administered for 12 weeks in people with CAH caused by 21-hydroxylase deficiency. The study enrolled 28 patients across 3 dose cohorts with classic CAH on a ...

SAN DIEGO - Neurocrine Biosciences, Inc. (NASDAQ:NBIX) has sponsored a supplement in The Journal of Clinical Endocrinology & Metabolism (JCEM) focusing on classic congenital adrenal hyperplasia (CAH), ...

due to 21-hydroxylase deficiency. The CAHtalyst studies were the largest-ever clinical trial program in classic CAH, including 285 pediatric and adult patients. The CAHtalyst Pediatric study included ...