In this work, we show that blockade of 12-LOX expression protects cortical neurons from Aβ-induced apoptosis, through disruption of a c-Jun-dependent apoptosis pathway. These findings suggest ...

Factors associated with adherence to chemotherapy guidelines in patients with non-small cell lung cancer (NSCLC). This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I. This abstract ...

Credit: Getty Images. VLX-1005 is a first-in-class, selective small molecule inhibitor of 12-lipoxygenase, a key target within the arachidonic acid pathway. The Food and Drug Administration (FDA ...

The company is currently developing therapeutics targeting 12-lipoxygenase (12-LOX). The new funding will be used to support the pre-clinical development of therapeutics to block the 12-LOX enzyme ...