这篇综述系统阐述了阿尔茨海默病（AD）中Aβ和tau蛋白协同致病的分子机制，揭示了二者通过β-片层结构（β-sheet）形成神经毒性聚集体的关键特征。作者创新性提出双重靶向策略——通过抑制Aβ 42 的17LVF 19 和tau的275VQIINK 280 /306VQIVYK 311 等关键结构域，或利用EGCG、姜黄素等天然化合物破坏疏水相互 ...

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Counterintuitively, the exceptional strength of silks comes from β-sheet nanocrystals in which the key molecular interactions are weak hydrogen bonds. Simulations now show that nanoconfinement ...

For example, β-sheets, which are sheet-like structures formed via hydrogen bonds between adjacent peptide strands, play a crucial role in protein stability and folding.

β-Sheets Form Early. The Aβ β-sheet signal (yellow and red) is absent in the transgenic APP mouse cortex at one month (left), appears at two (middle), and intensifies at three (right), when plaques ...

Ingram and colleagues favor a theory of Aβ toxicity whereby soluble β-sheet-containing protofibrils or fibrils induce Ca2+ influx through AMPA glutamate receptors. "We hypothesize that those neurons ...

Engineering: β-sheet engineering enhances IsPETase for PET depolymerization. Higher Education Press . Journal Engineering DOI 10.1016/j.eng.2024.10.015 ...

The research revealed that the polyQ fibril core consists of stacked β-sheets, each formed by antiparallel β-strands with minimal turns. These sheets are tightly packed, devoid of water, and ...

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease. ... such as β-sheets.